Enclomiphene
Experience the power of transformation with Enclomiphene – your path to renewed vigor and peak performance awaits.
In Men, Enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.
Enclomiphene, a selective estrogen receptor modulator (SERM), operates by binding to estrogen receptors in the hypothalamus, a region of the brain that plays a crucial role in regulating hormonal balance. By doing so, enclomiphene blocks the negative feedback effects of estrogen, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This heightened GnRH production subsequently stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), ultimately leading to the stimulation of testosterone production in men.
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The science of Enclomiphene
Active ingredients
Enclomiphene citrate, the active pharmaceutical ingredient, is the primary component of enclomiphene. It's formulated with inactive ingredients like microcrystalline cellulose, lactose monohydrate, magnesium stearate, and colloidal silicon dioxide to form tablets for oral administration.
Mechanism
Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.
History
Enclomiphene, is a non-FDA-approved medication that has garnered attention for its off-label application in the treatment of hypogonadism in males. It is an isomer of Clomiphene Citrate (brand name: Clomid), an FDA approved medication for the indication ovulatory dysfunction in women desiring pregnancy. Unlike its conventional use, enclomiphene's potential in managing low testosterone levels is a newer exploration. While the FDA has not specifically approved enclomiphene for hypogonadism, healthcare professionals consider its use for this purpose.A growing body of evidence suggests that enclomiphene may be a rapid and more effective treatment than Clomiphene citrate for treating secondary hypogonadism in men. Male secondary hypogonadism is a clinical syndrome caused by androgen deficiency attributed to the hypothalamic-pituitary-gonadal (HPG) axis. Initial studies indicate that Enclomiphene citrate possesses distinct advantages over Clomid (clomiphene citrate) and aromatase inhibitors for managing secondary hypogonadism. Firstly, enclomiphene citrate is the trans-isomer of clomiphene citrate and exhibits higher potency in stimulating the hypothalamic-pituitary-gonadal axis. This improved specificity enables enclomiphene citrate to effectively increase testosterone levels while minimizing estrogen-related side effects. Moreover, unlike aromatase inhibitors, enclomiphene citrate does not inhibit the aromatase enzyme responsible for converting testosterone into estrogen. This property allows enclomiphene citrate to maintain appropriate estrogen levels, contributing to better overall hormonal balance.
How to get Enclomiphene
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Frequently Asked Questions
Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.
No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.
No, enclomiphene is an alternative to TRT.
Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism. Hypogonadism is a condition in which the testes do not produce enough testosterone.
Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.
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Important Safety Information
Common side effects include (% = percentage of patients that experienced side effects during the clinical trial)
- Headache (3.3%)
- Nausea (2.1%)
- Diarrhea (1.9%)
- Common cold (1.7%)
- Hot flush (1.7%)
- Joint pain (1.2%)
- Dizziness (1%)
- Muscle spasms (0.9%)
- Fatigue (0.6%)
- Increased appetite (0.6%)
- Aggression (0.5%)
- Irritability (0.5%)
- Acne (0.5%)
- Increased libido
- Mood swings
Enclomiphene is potentially contraindicated in members who meet any of the following criteria and further assessment should be completed by the Superpower clinician and documented prior to the prescription of Enclomiphene:
- Female sex (assigned at birth)
- History of breast, endometrial (uterine), ovarian, or prostate cancer.
- History or pre-existing risk of blood clots
- History of heart disease
- History of liver disease
- Presence of current pituitary adenoma
- Uncontrolled adrenal or thyroid dysfunction
- Known allergy to enclomiphene or clomiphene
- History of mania, bipolar disorder, or current manic symptoms (d/t risk of mood swings)
Pregnancy Risks: Enclomiphene is not recommended for use during pregnancy due to a lack of data from controlled studies in humans. The FDA has not assigned a pregnancy risk category to the substance.
Enclomiphene's interactions with other medications should be carefully assessed to ensure optimal safety and efficacy. Individuals using drugs metabolized by the liver, especially those affecting the cytochrome P450 system, may experience altered metabolism when concurrently using enclomiphene. Additionally, caution is advised when combining enclomiphene with other hormonal therapies, as potential synergistic or antagonistic effects could influence overall therapeutic outcomes. It is crucial for healthcare professionals to thoroughly review a patient's medication profile and consider potential interactions before prescribing enclomiphene.
For Superpower Members, text your private concierge at any time with any question